Structural Biochemistry Lab

Structural Biochemistry Engineering - Quota 150 Responsible Prof. Fabio Tanfani	Research Activity
	Staff
	Equipment

Research Activity	The research activity is focused on the structural-functional relationships in soluble and membrane proteins. Circular dichroism, fluorescence spectroscopy and Fourier transform infrared spectroscopy are the main spectroscopic techniques used to study the protein structure.
Structural/functional characterization and potential applications of lipocalins, a family of proteins able to bind small hydrophobic molecules		Studies on the stability, aggregation and fibrillation of amyloidogenic proteins

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Interaction of proteins with exogenous and biologically active molecules		Interaction of proteins with biological model membranes

Staff
		Prof. Andrea Antonino Scirè tel. 071 2204662 mail a.a.scire@univpm.it		Dott. Beatrice Maggiore Dottoranda mail b.maggiore@univpm.it

Equipment
Perkin-Elmer 1760-X FT-IR spectrometer with DTGS detector and SPECTRUM software for data acquisition and analysis. The spectrometer is equipped with an air-dryer and a thermostated cell.
Nicolet NEXUS FT-IR Spectrometer equipped with DTGS and MCT detectors, air-dryer, thermostated cell, OMNIC and GRAMS32 softwares and "rapid scan" to obtain spectra in microseconds scale.		The Nicolet NEXUS FT-IR Spectrometer i salso equipped with:
		(a) ATR (attenuated total reflectance) for liquid, gel and solid samples analysis and (b) "grazing angle" accessory (specular reflectance) for the analysis of thin films on surfaces		A diamond anvil cell for measurements of biological samples at high pressures.

In the Lab are also available:
A JASCO J-500 Circular dicroism spectrometer		UV-VIS spectrophotometers		Two spectrofluorometers equipped with polarizers and thermostated cell

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